Effect of laparoscopic cholecystectomy at different time after endoscopic retrograde cholangiopancreatography on pain stress response in elderly patients with cholecystolithiasis and choledocholithiasis
Objective To investigate the effect of laparoscopic cholecystectomy at different time after endoscopic retrograde cholangiopancreatography in the treatment of elderly patients with cholecystolithiasis and choledocholithiasis.Methods A total of 120 elderly patients with cholecystolithiasis and choledocholithiasis from August 2019 to August 2022 were selected as the research objects.According to the different time of laparoscopic cholecystectomy after endoscopic retrograde cholangiopancreatography,the patients were divided into group A and group B,with 60 cases in each group.The group A underwent laparoscopic cholecystectomy within 3 d after endoscopic retrograde cholangiopancreatography,and the group B underwent laparoscopic cholecystectomy after 3 d of operation.The surgical effects of the two groups were compared.Results After operation,the levels of interleukin-6(IL-6),C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)in the group A were lower than those in the group B(P<0.05).After operation,the levels of bradykinin(BK),substance P(SP)and prostaglandin E2(PGE2)in the group A were lower than those in the group B(P<0.05).The total incidence of postoperative complications in the group A was lower than that in the group B(P<0.05).Conclusion Laparoscopic cholecystectomy within 3 d after endoscopic retrograde cholangiopancreatography can relieve the inflammatory response and pain stress response in elderly patients with cholecystolithiasis and choledocholithiasis,and reduce the incidence of postoperative complications,which is worthy of promotion.
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