首页|血清BDNF、VitB12、Tau蛋白水平与缺氧缺血性脑病早产儿脑神经发育的相关性分析

血清BDNF、VitB12、Tau蛋白水平与缺氧缺血性脑病早产儿脑神经发育的相关性分析

扫码查看
目的 探究血清脑源性神经营养因子(BDNF)、维生素B12(VitB12)、Tau蛋白水平与缺氧缺血性脑病早产儿脑神经发育的相关性.方法 选取 2020 年1月至2023年 6月收治的 80例缺氧缺血性脑病早产儿作为患儿组,另选取同期 80 例健康新生儿作为健康组.检测新生儿血清BDNF、VitB12、Tau蛋白水平,评估新生儿神经行为评定法(NBNA)评分,分析血清BDNF、VitB12、Tau蛋白水平与NBNA评分的相关性.结果 出生后 3d,患儿组的BDNF、VitB12 水平及NBNA评分低于健康组,Tau蛋白水平高于健康组,差异具有统计学意义(P<0.05).CT检查结果显示,轻度组33 例,中度组35例,重度组 12例;出生后3d,不同疾病程度患儿的BDNF、VitB12、Tau蛋白水平及NBNA评分比较,差异具有统计学意义(P<0.05).患儿组出生后14d的BDNF、VitB12 水平及NBNA评分高于出生后3 d,Tau蛋白水平低于出生后3d,差异具有统计学意义(P<0.05).Pearson相关性分析结果显示,BDNF、VitB12 水平与NBNA评分呈正相关(r=0.473、0.435,P<0.05);Tau蛋白水平与NBNA评分呈负相关(r=-0.411,P<0.05).结论 血清BDNF、VitB12 水平与缺氧缺血性脑病早产儿脑神经发育呈正相关,Tau蛋白水平与缺氧缺血性脑病早产儿脑神经发育呈负相关.
Correlation analysis of serum BDNF,VitB12 and Tau protein levels with brain nerve development in premature infants with hypoxic-ischemic encephalopathy
Objective To investigate the correlation between serum brain-derived neurotrophic factor(BDNF),vitamin B12(VitB12),Tau protein levels with brain nerve development in premature infants with hypoxic-ischemic encephalopathy.Methods A total of 80 premature infants with hypoxic-ischemic encephalopathy admitted from January 2020 to June 2023 were selected as the sickchildren group,and 80 healthy newborns in the same period were selected as the healthy group.The levels of serum BDNF,VitB12 and Tau protein in neonates were detected,and the Neonatal Behavioral Neurological Assessment(NBNA)score was evaluated.The correlation between serum BDNF,VitB12,Tau protein levels and NBNA score were analyzed.Results At 3 d after birth,the levels of BDNF,VitB12 and NBNA score in the sickchildren group were lower than those in the healthy group,the level of Tau protein was higher than that in the healthy group,and the differences were statistically significant(P<0.05).The results of CT examination showed that there were 33 cases in the mild group,35 cases in the moderate group and 12 cases in the severe group;at 3 d after birth,there were statistically significant differences in BDNF,VitB12,Tau protein levels and NBNA score among children with different degrees of disease(P<0.05).The levels of BDNF,VitB12 and NBNA score at 14 d after birth were higher than those at 3 d after birth,the level of Tau protein was lower than that at 3 d after birth,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that the levels of BDNF and VitB12 were positively correlated with NBNA score(r=0.473,0.435,P<0.05);Tau protein level was negatively correlated with NBNA score(r=-0.411,P<0.05).Conclusion The levels of serum BDNF and VitB12 are positively correlated with the development of brain nerve in premature infants with hypoxic-ischemic encephalopathy,and the level of Tau protein is negatively correlated with the development of brain nerve in premature infants with hypoxic-ischemic encephalopathy.

hypoxic-ischemic encephalopathypremature infantbrain-derived neurotrophic factorvita-min B12Tau proteinbrain nerve development

曹玲、高玉春、王晶

展开 >

建湖县人民医院儿科,江苏 盐城,224700

缺氧缺血性脑病 早产儿 脑源性神经营养因子 维生素B12 Tau蛋白 脑神经发育

江苏医药职业学院校地协同创新研究项目(2023)

20239232

2024

临床医学研究与实践

临床医学研究与实践

ISSN:
年,卷(期):2024.9(18)