Effects of dexmedetomidine and propofol on respiration and circulation in elderly patients undergoing total knee arthroplasty under epidural anesthesia
Objective To analyze the application effects of dexmedetomidine and propofol in elderly patients undergoing total knee arthroplasty(TKA)under epidural anesthesia.Methods A total of 82 elderly patients who received TKA treatment in our hospital from May 2021 to December 2022 were selected as the research objects,and the patients were divided into control group(41 cases,propofol)and study group(41 cases,dexmedetomidine)according to the difference of treatment plan.The vital signs,postoperative recovery and infection indexes of the two groups were compared.Results After loading dose(T1)to the end of operation(T4),the mean arterial pressure(MAP),saturation of peripheral oxygen(SpO2)and respiratory rate(RR)in the study group were higher than those in the control group,and the partial pressure of end-tidal carbon dioxide(PETCO2)was lower than that in the control group(P<0.05);from T1 to T4,there was no significant difference in heart rate(HR)between the two groups(P>0.05).The Visual Analogue Score(VAS)and Richmond Agitation and Sedation Scale(RASS)scores of the study group were lower than those of the control group(P<0.05).After operation,the C-reactive protein(CRP),procalcitonin(PCT)levels and white blood cell count(WBC)in the two groups were higher than those before operation,but those in the study group were lower than the control group(P<0.05).Conclusion The dexmedetomidine applied in elderly patients undergoing TKA under epidural anesthesia can obtain a more ideal sedative effect,which can reduce perioperative stress response,with little effect on respiration and circulation,and has higher application value.
epidural anesthesiatotal knee arthroplastydexmetomidinepropofolelderly patientrespiration and circulation
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