Effects of different doses of propofol combined with etomidate on anesthetic effect and hemodynamic parameters in patients undergoing transurethral resection of bladder tumor
Objective To investigate the effects of different doses of propofol combined with etomidate on anesthesia effect and hemodynamic parameters in patients undergoing transurethral resection of bladder tumor.Methods From September 2019 to September 2022,100 patients undergoing transurethral resection of bladder tumor were selected.All patients received general anesthesia.According to the different doses of propofol combined with etomidate,the patients were divided into group A and group B,with 50 cases in each group.The group A received 1.5 mg/kg propofol combined with 0.075 mg/kg etomidate,and the group B received 1 mg/kg propofol combined with 0.075 mg/kg etomidate.The anesthetic effects of the two groups were compared.Results From anesthesia induction(T1)to the end of operation(T4),the Observer's Assessment of Alterness/Sedation Scale(OAA/S)score in the group A was higher than that in the group B(P<0.05).At T1-T4,the mean artery pressure(MAP)and heart rate(HR)in the group A were lower than those in the group B(P<0.05).At T4,the levels of C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the group A were lower than those in the group B(P<0.05).There were no significant differences in recovery time,extubation time,recovery room retention time and hospitalization time between the two groups(P>0.05).Conclusion 1.5 mg/kg propofol combined with 0.075 mg/kg etomidate can improve the anesthetic effect of patients undergoing transurethral resection of bladder tumor,maintain the stability of hemodynamic parameters,reduce the inflammatory response of the body,do not increase the incidence of adverse reactions,and has the high quality of postoperative anesthesia recovery,which is worthy of promotion.
propofoletomidatetransurethral resection of bladder tumoranesthetic effecthemodynamics
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