Objective To analyze the predictive value of neutrophilic-to-lymphocyte ratio(NLR)and chohnesterase/albumin(ChE/ALB)for chronic obstructive pulmonary disease(COPD)and COPD with lower respiratory tract infection.Methods A total of 637 COPD patients and 260 healthy people(control group)who visited Yingshan Hospital of West China Hospital of Sichuan University from January 1 to September 30,2022 were selected as the research objects.According to whether the patients were complicated with lower respiratory tract infection,the patients were divided into COPD with lower respiratory tract infection group(224 cases)and COPD without lower respiratory tract infection group(413 cases).The medical record system was used to obtain the general data of the patients,and the laboratory information system was used to obtain the neutrophil count,lymphocyte count,levels of ChE and ALB test results of the cases,and the NLR and ChE/ALB were calculated.Receiver operating characteristic(ROC)curve was used to analyze the value of NLR and ChE/ALB in predicting COPD or predicting COPD with lower respiratory tract infection.Results The NLR of the COPD with lower respiratory tract infection group was significantly higher than that in the COPD without lower respiratory tract infection group and the control group(P<0.05);the NLR of the COPD without lower respiratory tract infection group was significantly higher than that in the control group(P<0.05).The ChE/ALB of the COPD with lower respiratory tract infection group was less than that in the COPD without lower respiratory tract infection group and the control group(P<0.05);the ChE/ALB of the COPD without lower respiratory tract infection group was less than that in the control group(P<0.05).The area under the curve(AUC)of combined NLR and ChE/ALB in predicting COPD with lower respiratory tract infection was about 0.929,and the AUC of combined prediction of COPD was about 0.820,which was higher than that of NLR or ChE/ALB alone prediction(P<0.05).Conclusion The increase of NLR and the decrease of ChE/ALB have a certain correlation with COPD and COPD with lower respiratory tract infection,which can be used as predictors,the combination of the two has higher diagnostic efficiency.
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