Effect of Shensong Yangxin capsules combined with sacubitril valsartan in the treatment of paroxysmal atrial fibrillation complicated with cardiac insufficiency and its influences on cardiovascular adverse events
Objective To analyze the effect of Shensong Yangxin capsule combined with sacubitril valsartan in the treatment of paroxysmal atrial fibrillation complicated with cardiac insufficiency and its influences on cardiovascular adverse events.Methods A total of 76 patients with paroxysmal atrial fibrillation complicated with cardiac insufficiency admitted in our hospital from February 2020 to February 2023 were selected as the research objects,and the patients were randomly divided into routine group(38 cases,sacubitril valsartan treatment)and observation group(38 cases,Shensong Yangxin capsule combined with sacubitril valsartan treatment).The clinical efficacy,cardiac function indexes,heart rate variability indexes,cardiovascular adverse events and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the routine group(P<0.05).After treatment,the left ventricular ejection fraction(LVEF),standard deviation of the R-R interval(SDNN)and root mean square of successive R-R interval differences(rMSSD)in the observation group were significantly higher than those in the routine group,while the left ventricular end-systolic diameter(LVESD),left ventricular end-systolic volume(LVESV)and left ventricular end-diastolic volume(LVEDV)were significantly lower than those in the routine group(P<0.05).The total incidence of cardiovascular adverse events during treatment in the observation group was significantly lower than that in the routine group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion Shensong Yangxin capsule combined with sacubitril valsartan in the treatment of patients with paroxysmal atrial fibrillation complicated with cardiac insufficiency can obtain safe and efficient ideal effect.
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