肝糖异生及其在2型糖尿病中的作用研究进展
Research progress of hepatic gluconeogenesis and its role in type 2 diabetes mellitus
脱伟旺 1张朝宁 1陈瑞 1刘聪聪 1余臣祖1
作者信息
- 1. 甘肃中医药大学,甘肃 兰州,730000
- 折叠
摘要
2 型糖尿病(T2DM)的主要特征是胰岛素抵抗(IR),其表现是抑制肝糖输出的效应减弱、肝糖异生异常表达.糖异生主要在肝脏中发生,其正常转运保证了机体的血糖处于正常稳态水平.本文综述了肝糖异生及其调控过程、肝糖异生在T2DM发病及治疗中的作用研究进展,以期为临床治疗T2DM提供参考.
Abstract
The main feature of type 2 diabetes mellitus(T2DM)is insulin resistance(IR),which is characterized by decreased effect of inhibiting hepatic glucose output and abnormal expression of hepatic gluconeogenesis.Gluconeogenesis mainly occurs in the hepar,and its normal transport ensures that the body's blood glucose is at a normal steady-state level.This article reviews the research progress of hepatic gluconeogenesis and its regulation process,and the role of hepatic gluconeogenesis in the pathogenesis and treatment of T2DM,in order to provide reference for clinical treatment of T2DM.
关键词
肝脏/糖异生/2型糖尿病Key words
hepar/gluconeogenesis/type 2 diabetes mellitus引用本文复制引用
基金项目
甘肃中医药大学科学研究与创新基金(2022)(2022KCZD-2)
出版年
2024
NETL
NSTL
万方数据