Analysis of the distribution and drug resistance monitoring of pathogenic bacteria in sputum culture of children with bronchopneumonia in a certain hospital from 2021 to 2022
Objective To investigate the distribution and drug resistance of pathogenic bacteria in sputum culture of children with bronchopneumonia in a certain hospital from 2021 to 2022,and to provide corresponding references for clinical rational drug use.Methods A total of 1 590 children with bronchopneumonia admitted in the pediatric department from October 2021 to December 2022 were selected as the research objects,sputum culture tests were performed on all children,and the distribution and drug resistance of pathogenic bacteria in sputum culture were analyzed.Results Among 1 590 children,306 cases were positive in sputum culture,and the positive rate was 19.25％.A total of 346 strains of pathogenic bacteria were isolated,of which 171 strains were Gram-negative bacteria,accounting for 49.42％,mainly Haemophilus influenzae(84 strains,accounting for 24.28％);157 strains were Gram-positive bacteria,accounting for 45.38％,mainly Staphylococcus aureus(54 strains,accounting for 15.61％)and Streptococcus pneumoniae(96 strains,accounting for 27.75％);18 strains were fungi,accounting for 5.20％,mainly Candida albicans(11 strains,accounting for 3.18％).Haemophilus influenzae had high drug resistance rate to ampicillin,cefaclor,cefuroxime and cotrimoxazole,with 92.86％,92.86％,85.71％and 85.71％,respectively;it was sensitive to ceftriaxone,levofloxacin,azithromycin,meropenem.Staphylococcus aureus had the highest drug resistance rate to penicillin,with 87.04％,and the drug resistance rate to gentamicin,levofloxacin and moxifloxacin were relatively low,with 3.70％,7.41％and 5.56％,respectively.Streptococcus pneumoniae had high drug resistance rate to erythromycin,tetracycline and cotrimoxazole,with 100.00％,93.75％and 68.75％,respectively;it was sensitive to penicillin,linezolid and vancomycin.Conclusion Haemophilus influenzae,Staphylococcus aureus and Streptococcus pneumoniae are the main pathogenic bacteria causing pediatric bronchopneumonia in a certain hospital from 2021 to 2022,and their drug sensitivity results can guide clinical rational drug use.
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