Study on the clinical value of metabolism-related markers in benign prostatic hyperplasia
Objective Through the detection of glucose and lipid metabolism related indicators in elderly patients with benign prostatic hyperplasia(BPH),to evaluate the correlation between them and BPH,to explore the possibility of incorporating glucose and lipid metabolism related indicators into routine detection of BPH,and to further provide guidance for the treatment of elderly patients with BPH.Methods A total of 85 patients with BPH who were admitted in Zaozhuang Municipal Hospital from July 2021 to June 2022 were included in BPH group,and 54 healthy people who underwent physical examination in the hospital during the same period were included in healthy control group.The levels of glycated albumin(GA),serum albumin(ALB),total bile acid(TBA),1,5-anhydro-D-glucitol(1,5-AG),pyruvic acid(PYR)and glycosylated hemoglobin(HbA1c)of the two groups were detected.Pearson analysis was used to explore the correlation between BPH and each index,and the receiver operating characteristic(ROC)curve was drawn to evaluate the diagnostic value of related indicators for BPH with the area under the curve(AUC).Results The BMI of the BPH group was significantly higher than that of the healthy control group(P＜0.001).The levels of ALB and 1,5-AG in the BPH group were significantly lower than those in the healthy control group,and HbA1c was significantly higher than that in the healthy control group(P＜0.01).BMI and HbA1c were positively correlated with the occurrence of BPH,while ALB and 1,5-AG were negatively correlated with the occurrence of BPH(P＜0.05).The AUC of ALB,1,5-AG and HbA1c in diagnosis of BPH were 0.796,0.701 and 0.656,respectively.Conclusion The decrease of ALB 1,5-AG levels and the increase of HbA1c are risk factors for the disease progression of BPH patients.It is suggested that ALB,1,5-AG and HbA1c should be included in the routine detection of BPH.
benign prostatic hyperplasiaglycated albuminserum albumintotal bile acid1,5-anhydro-D-glucitolpyruvic acidglycosylated hemoglobin
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