目的 分析老年2型糖尿病(T2DM)患者发生抑郁的影响因素，为制定精准干预方案以减少抑郁发生提供理论依据。方法 采用便利抽样法选取2018年1月至2021年12月在某三甲医院老年病内分泌科接受治疗的242例老年T2DM患者作为研究对象，利用老年抑郁量表-15(GDS-15)评估患者发生抑郁的情况，根据纳入及排除标准最终纳入170例。收集患者的临床资料，用Fried衰弱表型定义量表、匹兹堡睡眠质量指数量表(PSQI)、老年人运动功能量表(GLFS)分别评定患者的衰弱、睡眠质量及运动功能。采用二分类Logistic回归分析探讨影响老年T2DM患者发生抑郁的因素。结果 170例老年T2DM患者中有51例发生抑郁(抑郁组)，119例未发生抑郁(非抑郁组)。两组的居住方式、低血糖次数、合并其他疾病及衰弱分类占比比较，差异具有统计学意义(P＜0。05);抑郁组的病程长于非抑郁组，甘油三酯(TG)、空腹血浆葡萄糖(FPG)、餐后2小时血糖(2 h PBG)水平、糖化血红蛋白(HbA1c)及Fried衰弱评分、PSQI、GLFS评分高于非抑郁组(P＜0。05)。多因素Logistic回归分析结果显示，运动相关指标、PSQI评分及居住方式是影响老年T2DM患者发生抑郁的因素(P＜0。05)。结论 老年T2DM患者抑郁发生率较高，需重点关注睡眠质量差、几乎不锻炼和独居的患者，并针对上述因素制定干预措施。
Investigation on the status quo of depression in 170 elderly patients with T2DM and analysis of its influencing factors
Objective To analyze the influencing factors of depression in elderly patients with type 2 diabetes mellitus(T2DM),and to provide a effective theoretical basis for formulating precise intervention programs to reduce the occurrence of depression.Methods A total of 242 elderly patients with T2DM who were treated in the endocrinology of geriatrics department of a tertiary hospital from January 2018 to December 2021 were selected as the research objects by convenient sampling method.The Geriatric Depression Scale-15(GDS-15)was used to evaluate the occurrence of depression in patients,and 170 patients were finally included according to the inclusion and exclusion criteria.The clinical data of the patients were collected,and the Fried Frailty Phenotype Definition Scale,Pittsburgh Sleep Quality Index(PSQI)and Geriatric Locomotive Function Scale(GLFS)were used to evaluate the frailty,sleep quality and motor function of the patients.Binary Logistic regression analysis was used to explore the influencing factors of depression in elderly patients with T2DM.Results Among the 170 elderly patients with T2DM,51 case had depression(depression group)and 119 case had no depression(non-depression group).There were statistically significant differences in the proportion of living style,times of hypoglycemia,combined with other diseases and frailty classification between the two groups(P＜0.05);the course of disease in the depression group was longer than that in the non-depression group,and the levels of triacylglycerol(TG),fasting plasma glucose(FPG),2 h postprandial blood glucose(2 h PBG),glycosylated hemoglobin(HbA1c)and Fried frailty score,PSQI and GLFS scores were higher than those in the non-depression group(P＜0.05).Multivariate Logistic regression analysis results showed that exercise-related indexes,PSQI score and living style were influencing factors for depression in elderly patients with T2DM(P＜0.05).Conclusion The incidence of depression in elderly patients with T2DM is high.It is necessary to focus on patients with poor sleep quality,almost no exercise and living alone,and to develop interventions for the above factors.
type 2 diabetes mellitusdepressionelderly patientfrailty
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