Analysis of influencing factors of systemic immune inflammatory index in patients with colorectal cancer and its influence on postoperative recurrence rate
Objective To explore the clinical significance of systemic immune inflammatory index(SII)in patients with colorectal cancer.Methods A retrospective analysis of 122 patients with colorectal cancer admitted from January 2019 to January 2021 was performed.SII was calculated before surgery in all patients.According to the results of SII,the patients were divided into high SII group(n=57)and low SII group(n=65).Multivariate Logistic regression analysis was used to explore the influencing factors of SII in patients with colorectal cancer;all patients were followed up for 2 years,the survival rate and tumor recurrence rate of the high SII group and the low SII group were recorded and compared at 6 months and 1,1.5 and 2 years after operation.Results There were statistically significant differences in Karnofsky Performance Status(KPS)score,carbohydrate antigen 125(CA125)level,tumor diameter,preoperative albuminuria(Alb)level and pathological TNM staging between the two groups(P＜0.05).Multivariate Logistic regression analysis result showed that tumor diameter＞5 cm,preoperative Alb＜35.00 g/L and pathological TNM stage T3-T4 were risk factors for SII in patients with colorectal cancer(P＜0.05).After 2 years of follow-up,no death occurred in both groups.At 6 months and 1 year after operation,there was no significant difference in tumor recurrence rate between the two groups(P＞0.05);at 1.5 and 2 years after operation,the tumor recurrence rate in the low SII group was lower than that in the high SII group,and the difference was statistically significant(P＜0.05).Conclusion SII has significant implications for tumor pathological features and postoperative recurrence of colorectal cancer patients,which is worthy of reference and application by clinical medical workers.
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