Effect of lamotrigine combined with low-dose sodium valproate in the treatment of newly diagnosed epilepsy and its influences on electroencephalogram indexes
Objective To explore the effect of lamotrigine combined with low-dose sodium valproate in the treatment of newly diagnosed epilepsy and its influences on electroencephalogram indexes.Methods A total of 100 patients with newly diagnosed epilepsy admitted from April 2020 to April 2022 were selected as the research objects,and the patient were divided into control group and observation group according to the random number table method,with 50 cases in each group.The control group was treated with low-dose sodium valproate,and the observation group was treated with lamotrigine on the basis of the control group.The frequency of seizures,duration of seizures,electroencephalogram indexes,neurological function and cognitive function were compared between the two groups.Results After treatment,the frequency of epileptic seizures in the observation group was lower than that in the control group,and the duration of seizures was shorter than that in the control group(P＜0.05).After treatment,the 8 wave,epileptic discharge and the number of involved leads of the observation group were lower than those of the control group,and the θ wave was higher than that of the control group(P＜0.05).After treatment,the levels of neuron-specific enolase(NSE)and myelin basic protein(MBP)in the observation group were lower than those in the control group,the scores of Mini-Mental State Examination(MMSE)and Montreal Cognitive Assessment(MoCA)were higher than those of the control group(P＜0.05).Conclusion The lamotrigine combined with low-dose sodium valproate in the treatment of newly diagnosed epilepsy has obvious effect.It can not only improve the electroencephalogram indexes,but also reduce the degree of nerve cell damage and promote the recovery of cognitive function.
NETL
NSTL
万方数据
