Effect of salviae miltiorrhizae and ligustrazine hydrochloride injection combined with ticagrelor in the treatment of acute myocardial infarction and its influences on myocardial injury markers and platelet factors
Objective To investigate the effect of salviae miltiorrhizae and ligustrazine hydrochloride injection combined with ticagrelor in the treatment of acute myocardial infarction and its influences on myocardial injury markers and platelet factors.Methods A total of 80 patients with acute myocardial infarction admitted from June 2020 to July 2022 were selected as the research objects and divided into control group and observation group according to the random number table method,with 40 cases in each group.The control group was treated with ticagrelor,and the observation group was treated with salviae miltiorrhizae and ligustrazine hydrochloride injection on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P＜0.05).After treatment,the levels of creatine kinase-MB(CK-MB),cardiac troponin I(cTnI)and N-terminal pro-brain natriuretic peptide(NT-proBNP)in the observation group were lower than those in the control group(P＜0.05).After treatment,the levels of platelet activating factor(PAF),granule membrane protein-140(GMP-140)and platelet factor 4(PF4)in the observation group were lower than those in the control group(P＜0.05).After treatment,the interventricular septal thickness(IVST)and left ventricular myocardial mass index(LVMI)in the observation group were lower than those in the control group(P＜0.05).Conclusion Salviae miltiorrhizae and ligustrazine hydrochloride injection combined with ticagrelor in the treatment of acute myocardial infarction has satisfactory effect,it can effectively reduce the levels of myocardial injury markers,inhibit the expression of platelet factors,and improve ventricular remodeling,which is worth promoting.
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