Effect of cetirizine hydrochloride drops combined with montelukast sodium chewable tablets on cough variant asthma in children and its influences on IgE,IL-4 and IL-8 levels
Objective To investigate the effect of cetirizine hydrochloride drops combined with montelukast sodium chewable tablets in the treatment of cough variant asthma in children.Methods A total of 76 children with cough variant asthma who were treated in our hospital from May 2020 to May 2022 were selected as the research objects and randomly divided into control group and observation group,with 38 cases in each group.The control group was treated with montelukast sodium chewable tablets,and the observation group was treated with cetirizine hydrochloride drops on the basis of the control group.The therapeutic effect,levels of inflammatory factors,pulmonary function indexes and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.74％,which was significantly higher than 76.32％in the control group,and the difference was statistically significant(P＜0.05).Before treatment,there were no significant differences in serum immunoglobulin E(IgE),interleukin-4(IL-4)and interleukin-8(IL-8)levels between the two groups(P＞0.05);after treatment,the levels of IgE,IL-4 and IL-8 in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Before treatment,there were no significant differences in peak expiratory flow(PEF),maximal mid-expiratory flow(MMEF25-75),25％maximum expiratory flow(MEF25)and 50％maximal expiratory flow(MEF50)between the two groups(P＞0.05);after treatment,the PEF,MMEF25-75,MEF25 and MEF50 in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The total incidence of adverse reactions in the observation group was 5.26％,which was significantly lower than 21.05％in the control group,and the difference was statistically significant(P＜0.05).Conclusion Cetirizine hydrochloride drops combined with montelukast sodium chewable tablets in the treatment of cough variant asthma in children has a significant effect.It can not only effectively inhibit the levels of IgE,IL-4 and IL-8,but also improve the lung function of children and reduce the incidence of adverse reactions,which is safe and worthy of promotion.
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