Effects of minimally invasive injection of pulmonary surfactant through gastric tube combined with nasal continuous positive airway pressure on blood oxygen status and inflammatory response in children with neonatal respiratory distress syndrome
Objective To analyze the effects of minimally invasive injection of pulmonary surfactant(PS)through gastric tube combined with nasal continuous positive airway pressure(NCPAP)on blood oxygen status and inflammatory response in children with neonatal respiratory distress syndrome(NRDS).Methods Sixty children with NRDS admitted from February 2017 to March 2022 were selected as the study subjects.According to the time of admission,the children were divided into control group(February 2017 to August 2019)and observation group(September 2019 to March 2022),with 30 cases in each group.The control group was treated with budesonide combined with NCPAP,and the observation group was treated with minimally invasive injection of PS through gastric tube on the basis of the control group.The therapeutic effects of the two groups were compared.Results Before treatment,there were no significant differences in partial pressure of oxygen in arterial blood(PaO2),partial pressure of carbon dioxide(PaCO2)and fraction of inspiration oxygen(FiO2)between the two groups(P＞0.05);after treatment,the PaO2 in the observation group was higher than that in the control group,and the PaCO2 and FiO2 were lower than those in the control group,and the differences were statistically significant(P＜0.05).Before treatment,there were no significant differences in the levels of C-reactive protein(CRP),interleukin-18(IL-18)and white blood cell count(WBC)between the two groups(P＞0.05);after treatment,the levels of CRP,IL-18 and WBC in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Before treatment,there were no significant differences in respiratory resistance(Rrs)and compliance of the respiratory system(Crs)between the two groups(P＞0.05);after treatment,the Rrs of the observation group was lower than that of the control group,and the Crs was higher than that of the control group,and the differences were statistically significant(P＜0.05).Conclusion Minimally invasive injection of PS through gastric tube combined with NCPAP can reduce the inflammatory response,diminish the incidence of complications,and promote the recovery of lung function and blood oxygen status in children with NRDS,which is worthy of promotion.
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