Effects of landiolol on heart rate variability and QT interval in patients with type Ⅱ diabetes during anesthesia induction with tracheal intubation
Objective To analyze the effects of landiolol on heart rate variability and QT interval in patients with type Ⅱ diabetes during anesthesia induction with tracheal intubation.Methods A total of 100 patients with type Ⅱ diabetes who underwent surgery under general anesthesia with tracheal intubation in our hospital from August 2020 to August 2022 were selected as the research objects.According to the difference of anesthesia induction methods,the patients were divided into the conventional group(50 cases,anesthesia induction with conventional normal saline)and the observation group(50 cases,anesthesia induction with landiolol).The anesthesia induction effects of the two groups were compared.Results Before anesthesia induction(T0),there were no significant differences in heart rate(HR),blood oxygen saturation(SpO2)and mean arterial pressure(MAP)between the two groups(P＞0.05);from immediately before intubation(T1)to 5 min after intubation(T4),the HR and MAP in the observation group were lower than those in the conventional group,and SpO2 was higher than that in the conventional group,and the differences were statistically significant(P＜0.05);during the whole anesthesia process,the fluctuation range of vital signs in the observation group was smaller than that in the conventional group.T0,there were no significant differences in low frequency(LF),high frequency(HF),LF/HF,total power(TP)and QT interval between the two groups(P＞0.05);from T1 to T4,LF,the LF/HF,TP and QT interval in the observation group were lower than those in the conventional group,and the differences were statistically significant(P＜0.05);from T1 to T4,there was no significant difference in HF between the two groups(P＞0.05).Conclusion In patients with type 2 diabetes who underwent surgery under general anesthesia with tracheal intubation,the choice of landiolol can effectively stabilize the patients'intraoperative vital signs,and reduce the intraoperative LF,LF/TF,TP and QT interval,in order to achieve the ideal anesthesia induction effect.
type Ⅱ diabetesanesthesia inductionlandiololvital signheart rate variabilityQT interval
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