Effect of Jinghua Weikang capsule combined with rabeprazole quadruple therapy on Hp infectious peptic ulcer and its influence on ulcer healing
Objective To investigate the effect of Jinghua Weikang capsule combined with rabeprazole quadruple therapy in the treatment of Helicobacter pylori(Hp)infectious peptic ulcer and its influence on ulcer healing.Methods A total of 76 patients with Hp infectious peptic ulcer admitted from March 2021 to March 2023 were selected as study objects and randomly divided into control group and observation group,with 38 cases in each group.The control group was treated with rabeprazole quadruple therapy,and the observation group was treated with Jinghua Weikang capsule on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P＜0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),high sensitivity C-reactive protein(hs-CRP)and procalcitonin(PCT)in the observation group were lower than those in the control group(P＜0.05).After treatment,the ulcer healing in the observation group was better than that in the control group(P＜0.05).After treatment,the scores of each dimension of World Health Organization Quality of Life Scale Brief(WHOQOL-BREF)in the observation group were higher than those in the control group(P＜0.05).Conclusion The Jinghua Weikang capsule combined with rabeprazole quadruple therapy in the treatment of Hp infectious peptic ulcer has significant effect,it can not only inhibit inflammatory infiltration,but also promote ulcer healing and improve the quality of life of patients.
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