Effect of ambroxol hydrochloride combined with terbutaline and subcutaneous specific immunotherapy on stable COPD with allergic rhinitis and its influence on matrix metalloproteinase level
Objective To investigate the effect of ambroxol hydrochloride combined with terbutaline and subcutaneous specific immunotherapy on stable chronic obstructive pulmonary disease(COPD)with allergic rhinitis.Methods A total of 50 patients with stable COPD and allergic rhinitis admitted in our hospital from June 2019 to June 2022 were selected as the research objects.According to the difference of treatment methods,the patients were divided into control group(25 cases,terbutaline+subcutaneous specific immunotherapy)and observation group(25 cases,combined with ambroxol hydrochloride treatment on the basis of the control group).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).After treatment,the levels of matrix metalloproteinase-9(MMP-9)and tissue inhibitor of metalloproteinase-1(TIMP-1)in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the levels of Toll-like receptor 4(TLR4)and programmed death-1(PD-1)in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the T helper cell 17(Th 17)and immunoglobin E(IgE)level in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Ambroxol hydrochloride combined with terbutaline and subcutaneous specific immunotherapy can effectively improve the clinical effect of patients with stable COPD and allergic rhinitis,regulate the level of matrix metalloproteinase,and improve the levels of inflammation,immunity and other related factors,which is worthy of promotion.
ambroxol hydrochlorideterbutalinesubcutaneous specific immunotherapychronic obstructive pulmonary diseaseallergic rhinitis
NETL
NSTL
万方数据
