Effect of sacubitril valsartan combined with telmisartan in the treatment of dilated cardiomyopathy and its influences on myocardial fibrosis and ventricular remodeling
Objective To investigate the effect of sacubitril valsartan combined with telmisartan in the treatment of dilated cardiomyopathy(DCM)and its influences on myocardial fibrosis and ventricular remodeling.Methods A total of 60 DCM patients admitted from January to December 2020 were selected as the research objects.According to the parity of admission number,the patients were divided into control group and observation group,with 30 cases in each group.The control group was treated with telmisartan,and the observation group was treated with sacubitril valsartan on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the levels of N-terminal pro-brain natriuretic peptide(NT-proBNP),soluble growth stimulating gene 2 protein(sST2)and matrix metalloproteinase-9(MMP-9)in the two groups decreased,the level of tissue inhibitor of metalloproteinase-1(TIMP-1)increased,those in the observation group were better than the control group,and the differences were statistically significant(P＜0.05).After treatment,the left ventricular end-diastolic diameter(LVEDD)and left ventricle end-systolic diameter(LVESD)in the observation group were smaller than those in the control group,the cardiac output(CO),left ventricular ejection fraction(LVEF)and stroke volume(SV)were higher than those in the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Sacubitril valsartan combined with telmisartan is effective in the treatment of DCM,which can inhibit ventricular remodeling,relieve myocardial fibrosis and improve cardiac function.It has important clinical application value.
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