Clinical effect of high-flux hemodialysis combined with hemodialysis filtration sequential therapy on chronic renal failure and its influences on calcium and phosphorus metabolism and prognosis
Objective To analyze the clinical effect of high-flux hemodialysis(HFHD)combined with hemodialysis filtration(HDF)sequential therapy on chronic renal failure(CRF).Methods A total of 90 CRF patients received in our hospital from January 2020 to December 2020 were selected as the research objects and randomly divided into conventional group(45 cases,routine HFHD therapy)and combined group(45 cases,HFHD combined with HDF sequential therapy).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the combined group was higher than that in the conventional group(P＜0.05).After treatment,the levels of blood urea nitrogen(BUN),serum creatinine(Scr),parathyroid hormone(PTH)and β2-microglobulin(β2-MG)in the combined group were lower than those in the conventional group,and the endogenous creatinine clearance rate(Ccr)was significantly higher than that in the conventional group(P＜0.05).After treatment,the level of calcium(Ca)in the combined group was higher than that in the conventional group,the levels of phosphorus(P),fibroblast growth factor-23(FGF-23),magnesium(Mg),calcitonin(CT)and alkaline phosphatase(ALP)were lower than those in the conventional group,and the differences were statistically significant(P＜0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and interleukin-8(IL-8)in the combined group were lower than those in the conventional group,the level of interleukin-10(IL-10)was higher than that in the conventional group,and the differences were statistically significant(P＜0.05).The total incidence of adverse reactions in the combined group was lower than that in the conventional group,and the difference was statistically significant(P＜0.05).Conclusion HFHD combined with HDF sequential therapy on CRF can achieve ideal effect.
chronic renal failurehigh-flux hemodialysishemodialysis filtrationsequential therapycalcium and phosphorus metabolism
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