Effects of concurrent hyperthermia and radiochemotherapy on tumor markers and expressions of miR-21 and miR-130 in patients with advanced cervical cancer
Objective To investigate the effects of concurrent hyperthermia and radiochemotherapy on tumor markers and expressions of miR-21 and miR-130 in patients with advanced cervical cancer.Methods A total of 100 patients with advanced cervical cancer admitted from March 2020 to March 2022 were selected and divided into control group and observation group according to the difference of treatment methods,with 50 cases in each group.The control group was treated with concurrent radiochemotherapy,and the observation group was treated with concurrent hyperthermia and radiochemotherapy.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P＜0.05).After treatment,the mRNA expression levels of B7 homolog 4(B7-H4),hypoxia inducible factor-1α(HIF-1α)and proliferating cell nuclear antigen(PCNA)in the observation group were lower than those in the control group(P＜0.05).After treatment,the CD3+and CD4+in the observation group were higher than those in the control group,and CD8+was lower than that in the control group(P＜0.05).After treatment,the expression levels of miR-21 and miR-130 in the observation group were lower than those in the control group(P＜0.05).The severity of nausea and vomiting and cystitis in the observation group were lower than those in the control group(P＜0.05).Conclusion Concurrent hyperthermia and radiochemotherapy can improve the therapeutic effect of patients with advanced cervical cancer,promote the reduction of tumor markers,improve immune function,down-regulate the expression levels of miR-21 and miR-130,and reduce the degree of adverse reactions,which is worthy of promotion and application.
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