Effect of acetylcysteine aerosol inhalation combined with azithromycin sequential therapy on mycoplasma pneumonia in children and its influences on related factors
Objective To investigate the effect of acetylcysteine aerosol inhalation combined with azithromycin sequential therapy on mycoplasma pneumonia in children and its influences on serum amylase like protein A(SAA),human cartilage glycoprotein-39(HC-gp39)and serum ferritin(SF)levels.Methods A total of 68 children with mycoplasma pneumonia admitted from May 2019 to May 2022 were selected as the research objects and divided into control group and observation group according to the random number table method,with 34 cases in each group.The control group was treated with azithromycin sequential therapy,and the observation group was treated with acetylcysteine aerosol inhalation on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P＜0.05).After treatment,the levels of superoxide dismutase(SOD)and catalase(CAT)in the observation group were higher than those in the control group,and the level of lipid peroxide(LPO)was lower than that in the control group(P＜0.05).After treatment,the CD3+and CD4+in the observation group were higher than those in the control group(P＜0.05).After treatment,the levels of SAA,HC-gp39 and SF in the observation group were lower than those in the control group(P＜0.05).Conclusion Acetylcysteine aerosol inhalation combined with azithromycin sequential therapy has significant effect in the treatment of mycoplasma pneumonia in children,it can not only reduce oxidative stress and improve immune function,but also down-regulate SAA,HC-gp39 and SF levels,which is worthy of application and promotion.
acetylcysteineaerosol inhalationazithromycinsequential therapymycoplasma pneumonia in children
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