Application of serum copeptin,urinary leukocyte esterase and urinary bacterial count in the diagnosis of urinary tract infection in patients with renal calculi
Objective To investigate the diagnostic value of serum copeptin(CPP),urinary leukocyte esterase(ULE)and urinary bacterial count on urinary tract infection(UTI)in patients with renal calculi.Methods A total of 140 patients with renal calculi admitted from January 2021 to June 2022 were selected as the research objects.All patients underwent urinary bacterial culture,and CPP,ULE and urinary bacterial count were detected.According to the occurrence of UTI,the patients were divided into UTI group and non-infection group.The CPP level,positive ULE and positive urinary bacterial count were compared between the two groups;Logistic regression was used to analyze the correlation between each indexes and UTI in patients with renal calculi;the receiver operator characteristic(ROC)curve was used to analyze the diagnostic efficacy of each indexes and the combination of the three;the distribution of pathogenic bacteria in the UTI group was recorded,and the CPP level,positive ULE and positive urinary bacterial count in patients with Gram-positive bacteria(G+)and Gram-negative bacteria(G-)infection were compared.Results The maximum stone diameter,proportion of staghorn calculi,CPP level,proportions of positive ULE and positive urinary bacterial count in the UTI group were higher than those in the non-infected group(P＜0.05).Logistic regression analysis results showed that maximum stone diameter,staghorn calculi,CPP,positive ULE and positive urinary bacterial count were the influencing factors of UTI in patients with renal calculi(P＜0.05).ROC curve analysis showed that the combined detection of CPP,ULE and urinary bacterial count has higher diagnosis efficacy for UTI in patients with renal calculi,the area under curve(AUC)was 0.929,the sensitivitiy was 92.86％,and the specificity was 92.86％.In the UTI group,G-was dominated by Escherichia coli and G+was dominated by Enterococcus faecalis.Conclusion The combined detection of CPP,ULE and urinary bacterial count has better diagnostic efficacy for UTI in patients with renal calculi.
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