Effect of Yiqi Fumai injection combined with levosimendan in the treatment of chronic heart failure and its influences on the expression of miR-30a and miR-101a
Objective To analyze the effect of Yiqi Fumai injection combined with levosimendan in the treatment of chronic heart failure and its influences on the expression of miR-30a and miR-101a.Methods A total of 80 patients with chronic heart failure admitted from June 2021 to June 2022 were selected as the research objects,and the patients were divided into control group(n=40,levosimendan)and observation group(n=40,Yiqi Fumai injection combined with levosimendan)by random number table method.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P＜0.05).After treatment,the levels of N-terminal pro-brain natriuretic peptide(NT-proBNP),free fatty acid(FFA)and activin A(ACT-A)in the observation group were lower than those in the control group(P＜0.05).After treatment,the levels of laminin(LN),hyaluronic acid(HA)and procollagen Ⅲ(PC Ⅲ)in the observation group were lower than those in the control group(P＜0.05).After treatment,the expression level of miR-30a in the observation group was lower than that in the control group,and the expression level of miR-101a was higher than that in the control group(P＜0.05).Conclusion Yiqi Fumai injection combined with levosimendan in the treatment of chronic heart failure can improve the therapeutic effect,promote the decrease of myocardial damage markers and myocardial fibrosis indexes,and regulate the expression levels of miR-30a and miR-101a.
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