Correlation between CRP,NLR and radiation pneumonitis in patients with locally advanced non-small cell lung cancer undergoing radiotherapy
Objective To investigate the correlation between C-reactive protein(CRP),neutrophil-to-lymphocyte ratio(NLR)and radiation pneumonitis in patients with locally advanced non-small cell lung cancer(NSCLC)undergoing radiotherapy.Methods The clinical data of 186 cases with locally advanced NSCLC who underwent intensity modulated radiation therapy were retrospectively analyzed.According to the occurrence of radiation pneumonitis,the patients were divided into pneumonia group and control group.The CRP level and NLR before and after radiotherapy were compared between the two groups.Logistic regression analysis was used to analyze the risk factors of radiation pneumonitis in patients with locally advanced NSCLC undergoing radiotherapy.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of each index for radiation pneumonitis in patients with locally advanced NSCLC undergoing radiotherapy.Results After radiotherapy,the CRP level and NLR in the pneumonia group were higher than those in the control group(P<0.05).There were significant differences in the proportion of chronic obstructive pulmonary disease,diabetes,lung exposure site,concurrent chemotherapy and sequential chemotherapy within 3 months after radiotherapy between the two groups(P<0.05).Multivariate Logitic regression analysis showed that elevated CRP level and NLR,chronic obstructive pulmonary disease and concurrent chemotherapy were independent risk factors for radiation pneumonitis in patients with locally advanced NSCLC undergoing radiotherapy(P<0.05).The ROC curve showed that the area under the curve(AUC)of CRP and NLR were 0.819 and 0.814,the optimal cut-off values were 10.5 mg/L and 5.1,the sensitivity was 0.846 and 0.908,and the specificity was 0.758 and 0.584.Conclusion The elevated CRP level and NLR are closely related to the occurrence of radiation pneumonitis in patients with locally advanced NSCLC undergoing radiotherapy,and have certain predictive value for it.
C-reactive proteinneutrophil-to-lymphocyte ratioradiation pneumonitisnon-small cell lung cancer
NETL
NSTL
万方数据
