Effect of budesonide formoterol powder inhalation combined with levocetirizine hydrochloride in the treatment of combined allergic rhinitis and asthma syndrome and its influences on allergic reaction and inflammatory factors levels
Objective To investigate the effect of budesonide formoterol powder inhalation combined with levocetirizine hydrochloride in the treatment of combined allergic rhinitis and asthma syndrome(CARAS)and its influences on allergic reaction and inflammatory factors levels.Methods A total of 100 patients with CARAS admitted from February 2019 to March 2022 were selected as the research objects,and the patients were divided into control group and observation group by random number table method,with 50 cases in each group.The control group was treated with levocetirizine hydrochloride,and the observation group was treated with budesonide formoterol powder inhalation on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the scores of nasal itching,sneezing,nasal congestion and dyspnea between the two groups(P>0.05);after treatment,the scores of nasal itching,sneezing,nasal congestion and dyspnea in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of interleukin-22(IL-22),interleukin-8(IL-8)and immunoglobulin E(IgE)between the two groups(P>0.05);after treatment,the levels of IL-22,IL-8 and IgE in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in forced vital capacity(FVC)and forced expiratory volume in the first second(FEV1)between the two groups(P>0.05);after treatment,the FVC and FEV1 in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The budesonide formoterol powder inhalation combined with levocetirizine hydrochloride in the treatment of CARAS has a significant effect.It can inhibit the levels of inflammatory factors,relieve allergic reactions,and improve the lung function of patients.
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