Value of interleukin-10 and systemic immune-inflammation index in predicting postoperative recurrence of non-muscle-invasive bladder cancer
Objective To investigate the value of interleukin-10(IL-10)and systemic immune-inflammation index(SII)in predicting recurrence after transurethral resection of bladder tumor(TURBt)in patients with non-muscle-invasive bladder cancer(NMIBC).Methods The clinical data of 147 patients with NMIBC undergoing TURBt in the urinary surgery department of the Affiliated Suqian Hospital of Xuzhou Medical University from January 2019 to December 2021 were retrospectively analyzed.The receiver operating characteristic(ROC)curves of IL-10,SII alone and combination in predicting postoperative recurrence of NMIBC patients were analyzed;the relationship between IL-10 and SII and clinicopathological features of NMIBC patients were analyzed;the recurrence-free survival curve of IL-10 and SII in NMIBC patients were compared;the influencing factors of postoperative recurrence in patients with NMIBC were analyzed.Results The follow-up time of 147 patients was 11-51 months,with an average of(35.60±7.80)months,of which 61 patients had recurrence,and the recurrence rate was 41.50%(61/147).The area under curve(AUC)of ROC curve of IL-10,SII alone and combination in predicting postoperative recurrence of NMIBC patients was 0.776,0.789 and 0.857,respectively.Multivariate Cox regression analysis results showed that tumor stage,tumor grade,IL-10 and SII were independent risk factors for postoperative recurrence of NMIBC patients(P<0.05).Conclusion IL-10 and SII are independent risk factors for postoperative recurrence in NMIBC patients,and can be considered as potential indicators for predicting postoperative recurrence in NMIBC patients in clinic.
non-muscle-invasive bladder cancertransurethral resection of bladder tumorinterleukin-10systemic immune-inflammation indexrecurrence
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