Effect of sacubitril valsartan sodium combined with recombinant human prourokinase in the treatment of acute myocardial infarction and its influence on cardiac function
Objective To explore the effect of sacubitril valsartan sodium combined with recombinant human prourokinase in the treatment of acute myocardial infarction and its influence on cardiac function.Methods A total of 80 patients with acute myocardial infarction admitted from February 2020 to March 2023 were selected as the research objects.According to the time of admission,the patients were divided into control group and observation group,with 40 cases in each group.The control group was treated with conventional symptomatic treatment combined with recombinant human prourokinase,and the observation group was treated with sacubitril valsartan sodium on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the left ventricular ejection fraction(LVEF),cardiac index(CI)and stroke volume(SV)in the observation group were bigger than those in the control group,and the left ventricular end-systolic diameter(LVESD)was smaller than that in the control group(P<0.05).After treatment,the levels of N-terminal pro-brain natriuretic peptide(NT-proBNP),myoglobin(Myo),creatine kinase MB isoenzyme(CK-MB)and cardiac troponin I(cTnI)in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The sacubitril valsartan sodium combined with recombinant human prourokinase in the treatment of acute myocardial infarction has a significant effect.It can not only alleviate myocardial injury and improve cardiac function,but also has high safety,which is worthy of promotion.
sacubitril valsartan sodiumrecombinant human prourokinaseacute myocardial infarctioncardiac functionmyocardial injury marker
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