Analysis of influencing factors of nonalcoholic fatty liver disease in obese children
Objective To explore the influencing factors of nonalcoholic fatty liver disease(NAFLD)in obese children,and to provide theoretical basis for clinical prevention and treatment.Methods A total of 99 children who were diagnosed as simple obesity in the inpatient department or outpatient department of Baoji Maternal and Child Health Care Hospital from January 2018 to October 2022 were selected as the research objects.According to the diagnostic criteria of NAFLD,the research objects were divided into NAFLD group and non-NAFLD group.The clinical data and biochemical test results of the children were collected.Binary Logistic regression analysis was used to explore the influencing factors of NAFLD in obese children,and the receiver operating characteristic(ROC)curve was drawn to construct the prediction model.Results Among 99 obese children,46 had NAFLD.The age of the NAFLD group was older than that of the non-NAFLD group,the proportion of male children,hypertension and abnormal glucose tolerance,and the body mass index(BMI),waist hip ratio(WHR),alanine transaminase(ALT),triacylglycerol(TG)levels and homeostatsis model assess ment insulin resistance index(HOMA-IR)were higher than those of the non-NAFLD group,the level of serum 25-hydroxyvitamin D3[25-(OH)D3]was lower than that in the non-NAFLD group,and the differences were statistically significant(P＜0.05).Multivariate regression analysis showed that WHR and HOMA-IR were independent influencing factors of NAFLD in obese children(P＜0.05).The area under the curve(AUC)of WHR and HOMA-IR in the diagnosis of NAFLD in obese children was 0.894 and 0.926,respectively,and the AUC of combined predictors was 0.956.Conclusion WHR and HOMA-IR are independent risk factors for NAFLD in obese children.Clinically,relevant metabolic indicators and liver imaging examinations of obese children should be actively detected to detect NAFLD in the early stage,and timely intervention measures are formulated to improve the prognosis.
万方数据
维普
