Effect of acarbose combined with calcitriol and calcium in the treatment of type 2 diabetes mellitus with osteoporosis and its influence on bone metabolism
Objective To analyze the effect of acarbose combined with calcitriol and calcium in the treatment of type 2 diabetes mellitus with osteoporosis and its influence on bone metabolism.Methods A total of 90 patients with type 2 diabetes mellitus and osteoporosis admitted in our hospital from June 2020 to June 2022 were selected and divided into control group and observation group by random number table method,with 45 cases in each group.The control group was treated with insulin combined with calcitriol and calcium,and the observation group was treated with acarbose combined with calcitriol and calcium.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P＜0.05).After treatment,the level of type Ⅰ collagen carboxy-terminal peptide β-specific sequence(β-CTX),expression of miR-144,NOD-like receptor protein 3(NLRP3)mRNA and monocyte chemotactic protein-1(MCP-1)level in the observation group were lower than those in the control group,and the levels of osteocalcin(OC),bone-specific alkaline phosphatase(B-ALP),and bone mineral density of Ward's triangle and L1-4 were higher than those in the control group(P＜0.05).Conclusion Acarbose combined with calcitriol and calcium in the treatment of type 2 diabetes mellitus with osteoporosis can improve the curative effect,promote the improvement of bone metabolism and bone mineral density,and also down-regulate the expression of miR-144,NLRP3 mRNA and MCP-1.
维普
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