Efficacy and safety of minocycline hydrochloride combined with Vitapex paste root canal injection in the treatment of combined periodontal-endodontic lesions
Objective To explore the efficacy and safety of minocycline hydrochloride combined with Vitapex paste root canal injection in the treatment of combined periodontal-endodontic lesions.Methods A total of 80 patients with combined periodontal-endodontic lesions admitted in our hospital from February 2020 to February 2023 were selected as the research objects.The patients were randomly divided into routine group and observation group,with 40 cases in each group.Both groups were given routine treatment,the routine group was treated with Vitapex paste root canal injection,and the observation group was treated with minocycline hydrochloride combined with Vitapex paste root canal injection.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the routine group(P＜0.05).After treatment,the probing depth(PD),attachment loss(AL),gingival index(GI),sulcus bleeding index(SBI)and plaque index(PLI)scores in the observation group were lower than those in the routine group(P＜0.05).After treatment,the levels of interleukin-1 β(IL-1β),interleukin-6(IL-6),C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the routine group(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05);the recurrence rate of acute and chronic pulpitis in the observation group was lower than that in the routine group(P＜0.05).Conclusion Minocycline hydrochloride combined with Vitapex paste root canal injection treatment can effectively improve the periodontal condition of patients with combined periodontal-endodontic lesions,quickly eliminate the inflammatory reaction,reduce the recurrence rate of acute and chronic pulpitis,and do not increase adverse reactions,and the curative effect is better.
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