Diagnostic value of procalcitonin in Gram-positive bacteria and Gram-negative bacteria of respiratory tract infection
Objective To investigate the diagnostic value of procalcitonin(PCT)in Gram-positive bacteria and Gram-negative bacteria in respiratory tract infection.Methods The samples were collected from 247 patients with positive bacterial culture of respiratory tract infection who were hospitalized in the respiratory department of Panjin Liaoyou Gem Flower Hospital from November 2021 to October 2022.According to the results of Gram staining,the patients were divided into Gram-positive bacterial infection group and Gram-negative bacterial infection group.After that,the respiratory tract specimen culture and PCT detection were performed.The PCT levels of different genders and between the two groups were compared between the Gram-positive bacteria infection group and the Gram-negative bacteria infection group.The receiver operating curve(ROC)was used to analyze the diagnostic efficacy of PCT for Gram-positive bacteria and Gram-negative bacteria.Results There were 57 cases of Gram-positive bacterial infection and 190 cases of Gram-negative bacterial infection;there was no significant difference in PCT level between different genders in Gram-positive bacterial infection group and Gram-negative bacterial infection group(P＞0.05).The serum PCT level in the Gram-positive bacterial infection group was significantly lower than that in the Gram-negative bacterial infection group(P＜0.05).The ROC curve showed that when the serum PCT concentration was 4.312 ng/mL as the cut-off value,the diagnostic efficacy for Gram-positive bacteria and Gram-negative bacteria was the highest.The area under curve(AUC)was 0.825(95％CI 0.771-0.853),the sensitivity was 82.50％,and the specificity was 70.30％.Conclusion According to the level of serum PCT,the infection of Gram-positive bacteria or Gram-negative bacteria in respiratory tract can be preliminarily identified,which provides a reference for the rational selection of antibiotics in the early stage of clinical treatment.
万方数据
维普
