Effects of hemoperfusion on serum CHE,DA,TGF-β1 and TNF-α levels in elderly patients with severe acute organophosphorus pesticide poisoning
Objective To analyze the efficacy and safety of hemoperfusion in the treatment of elderly patients with severe acute organophosphorus pesticide poisoning.Methods A total of 40 elderly patients with severe acute organophosphorus pesticide poisoning admitted in our hospital from January to December 2020 were selected as the research objects.The patients were divided into conventional group and observation group according to the treatment plan,with 20 cases in each group.The conventional group was given routine symptomatic treatment,and the observation group was given hemoperfusion treatment on the basis of the conventional group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the conventional group(P<0.05).The total dosage of atropine in the observation group was less than that in the conventional group,and the duration of coma,the recovery time of cholinesterase(CHE)activity and the length of hospitalization were significantly shorter than those in the conventional group(P<0.05).After treatment,the levels of CHE,dopamine(DA)and interferon-γ(IFN-γ)in the observation group were higher than those in the conventional group,and the levels of transforming growth factor-β1(TGF-β1),tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)were lower than those in the conventional group(P<0.05).The total incidence of complications in the observation group was significantly lower than that in the conventional group(P<0.05).Conclusion Hemoperfusion in the treatment of elderly patients with severe acute organophosphorus pesticide poisoning can achieve ideal comprehensive efficacy and high treatment safety.
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