Application effect of ulinastatin combined with continuous renal replacement therapy in patients with sepsis complicated with acute kidney injury and its influences on inflammation,stress and renal function indexes
Objective To explore the application effect of ulinastatin combined with continuous renal replacement therapy in patients with sepsis complicated with acute kidney injury.Methods A total of 58 patients with sepsis complicated with acute kidney injury admitted in our hospital were selected as the research objects,and the patients were divided into reference group and study group by drawing lots,with 29 cases in each group.The reference group was treated with continuous renal replacement therapy,and the study group was given ulinastatin on the basis of the reference group.The therapeutic effects of the two groups were compared.Results After 2 weeks of treatment,the levels of procalcitonin(PCT),C-reactive protein(CRP)and malondialdehyde(MDA)in the two groups decreased,and the level of glutathione peroxidase(GSH-Px)increased,and those in the study group were better than the reference group(P<0.05).After 2 weeks of treatment,the levels of tissue inhibitor of matrix metalloproteinase-2(TIMP-2),soluble triggering receptor expressed on myeloid cells-1(sTREM-1),neutrophil gelatinase associated lipocalin(NGAL),liver fatty acid binding protein(L-FABP),kidney injury molecule-1(KIM-1)and matrix metalloproteinase-9(MMP-9)in the two groups decreased,the level of cystatin C(CysC)increased,and those in the study group were better than the reference group(P<0.05).The continuous renal replacement therapy time and hospitalization time of the study group were shorter than those of the reference group(P<0.05);after 2 weeks of treatment,the Sepsis Related Organ Failure Assessment(SOFA)score of the study group was lower than that of the reference group(P<0.05).Conclusion The ulinastatin combined with continuous renal replacement therapy in patients with sepsis complicated with acute kidney injury has a significant application effect,which can effectively reduce the body's inflammation and stress response,improve the renal function,and promote the prognosis of the disease.
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