Effect of endoscopic rotary repeated open and close soft tissue clip hemostasis combined with octreotide and omeprazole in the treatment of non-variceal upper gastrointestinal bleeding and its influence on coagulation function
Objective To investigate the effect of endoscopic rotary repeated open and close soft tissue clip hemostasis combined with octreotide and omeprazole in the treatment of non-variceal upper gastrointestinal bleeding.Methods A total of 120 patients with non-variceal upper gastrointestinal bleeding admitted from January 2021 to December 2022 were selected and divided into control group and observation group by random number table method,with 60 cases in each group.The control group was treated with octreotide and omeprazole,and the observation group was treated with endoscopic rotary repeated open and close soft tissue clip hemostasis on the basis of the control group.The therapeutic effects of the two groups were compared.Results The immediate hemostasis rate and hemostasis efficiency of the observation group were higher than those of the control group,and the rebleeding rate at 72 h was lower than that of the control group(P<0.05).After treatment,the prothrombin time(PT)and activated partial thromboplastin time(APTT)in the observation group were shorter than those in the control group,D-dimer(D-D)level was lower than that in the control group,and the level of fibrinogen(FIB)was higher than that in the control group(P<0.05).After treatment,the alpha-granular membrane protein(CD62P)in the observation group was lower than that in the control group,and the blood platelet(PLT)and platelet aggregation ratio(PAR)were higher than those in the control group(P<0.05).Conclusion Endoscopic rotary repeated open and close soft tissue clip hemostasis combined with octreotide and omeprazole in the treatment of patients with non-variceal upper gastrointestinal bleeding can improve platelet activation function and coagulation function,and enhance the overall treatment effect.
rotary repeated open and close soft tissue clipoctreotideomeprazolenon-variceal upper
NETL
NSTL
万方数据
