Relationship between fractional exhaled nitric oxide and alveolar nitric oxide and small airway function in patients with chronic obstructive pulmonary disease
Objective To investigate the relationship between fractional exhaled nitric oxide(FeNO)and alveolar nitric oxide(CaNO)and small airway function in patients with chronic obstructive pulmonary disease(COPD).Methods Fifty patients with stable COPD who were recuperated in our hospital from June 2021 to March 2022 were selected as observation group,and 50 patients(excluding COPD)who were recuperated in our hospital during the same period were selected as control group.The pulmonary function indexes,FeNO50,FeNO200 and CaNO were detected in the two groups.Pearson correlation analysis was used to explore the relationship between FeNO200,CaNO and pulmonary function indexes.Results The pulmonary function indexes of the observation group were lower than those of the control group(P<0.05).The FeNO200 and CaNO of the observation group were higher than those of the control group(P<0.05).FeNO200 and CaNO in the observation group were negatively correlated with maximum expiratory flow at 25 percent(MEF25%),maximum expiratory flow at 50 percent(MEF50%)and maximal med-expiratory flow(MMEF75/25)(P<0.05).Conclusion FeNO200 and CaNO are elevated in COPD patients,which can be used as biomarkers of small airway inflammation in COPD patients.
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