临床医学研究与实践2024，Vol.9Issue(24) ：18-21.DOI:10.19347/j.cnki.2096-1413.202424005

沙库巴曲缬沙坦对房颤伴心功能不全、心功能正常射频消融术后患者心功能及房颤复发率的影响

Effects of sacubitril valsartan on cardiac function and recurrence rate of atrial fibrillation in patients with atrial fibrillation complicated with cardiac insufficiency and normal cardiac function after radiofrequency ablation

吴金家 宋旭东 廖佩娟 李华华 谭剑炼 莫善洪
临床医学研究与实践2024，Vol.9Issue(24) ：18-21.DOI:10.19347/j.cnki.2096-1413.202424005
✕
  • NETL
  • NSTL
  • 万方数据

沙库巴曲缬沙坦对房颤伴心功能不全、心功能正常射频消融术后患者心功能及房颤复发率的影响

Effects of sacubitril valsartan on cardiac function and recurrence rate of atrial fibrillation in patients with atrial fibrillation complicated with cardiac insufficiency and normal cardiac function after radiofrequency ablation

吴金家 1宋旭东 2廖佩娟 1李华华 1谭剑炼 1莫善洪1
扫码查看

作者信息

  • 1. 广西贺州市人民医院,广西 贺州,524800
  • 2. 南方医科大学珠江医院,广东 广州,510280
  • 折叠

摘要

目的 比较沙库巴曲缬沙坦对房颤伴心功能不全、心功能正常射频消融术后患者心功能及房颤复发率的影响.方法 选取 47例经射频消融术治疗的房颤患者,根据心功能情况将其分为心功能不全组(18例)与心功能正常组(29 例).两组均给予沙库巴曲缬沙坦治疗,比较两组的治疗效果.结果 术后随访1年,两组的超敏C反应蛋白(hs-CRP)水平低于术后即刻,差异具有统计学意义(P＜0.05);术后即刻,心功能不全组的N-末端B型脑钠肽前体(NT-proBNP)水平高于心功能正常组,差异具有统计学意义(P＜0.05);术后随访 1年,心功能不全组的NT-proBNP水平低于术后即刻,差异具有统计学意义(P＜0.05).术后随访 1 年,心功能不全组的左心室舒张末期内径(LVEDD)、左心房前后径(LAD)低于术后即刻,左心室射血分数(LVEF)高于术后即刻,差异具有统计学意义(P＜0.05).术后随访 1年,共 4 例房颤复发(8.51%),其中心功能不全组2 例(11.11%),心功能正常组 2 例(6.90%),两组间比较,差异无统计学意义(P＞0.05).结论 沙库巴曲缬沙坦应用于房颤伴心功能不全射频消融术后患者,可改善心功能和心脏重构,并达到与心功能正常者相同的效果.

Abstract

Objective To compare the effects of sacubitril valsartan on cardiac function and recurrence rate of atrial fibrillation in patients with atrial fibrillation complicated with cardiac insufficiency and normal cardiac function after radiofrequency ablation.Methods A total of 47 patients with atrial fibrillation treated by radiofrequency ablation were selected and divided into cardiac insufficiency group(18 cases)and normal cardiac function group(29 cases)according to cardiac function.Both groups were treated with sacubitril valsartan,and the therapeutic effects of the two groups were compared.Results At 1 year of postoperative follow-up,the level of hypersensitive C-reactive protein(hs-CRP)in the two groups was lower than that immediately after operation,and the difference was statistically significant(P<0.05);immediately after operation,the level of N-terminal pro-B-type natriuretic peptide(NT-proBNP)in the cardiac insufficiency group was higher than that in the normal cardiac function group,and the difference was statistically significant(P<0.05);at 1 year of postoperative follow-up,the level of NT-proBNP in the cardiac insufficiency group was lower than that immediately after operation,and the difference was statistically significant(P<0.05).At 1 year of postoperative follow-up,left ventricular end diastolic diameter(LVEDD)and left atrial diameter(LAD)in the cardiac insufficiency group were lower than those immediately after operation,left ventricular ejection fraction(LVEF)was higher than that immediately after operation,and the differences were statistically significant(P<0.05).At 1 year of postoperative follow-up,4 cases(8.51%)of atrial fibrillation recurred,including 2 cases(11.11%)in the cardiac insufficiency group and 2 cases(6.90%)in the normal cardiac function group,and there was no statically significant difference between the two groups(P>0.05).Conclusion The application of sacubitril valsartan in patients with atrial fibrillation and cardiac insufficiency after radiofre-quency ablation can improve cardiac function and cardiac remodeling,and achieve the same effect as those with normal cardiac function.

关键词

沙库巴曲缬沙坦/房颤/射频消融/心功能

Key words

sacubitril valsartan/atrial fibrillation/radiofrequency ablation/cardiac function

引用本文复制引用

基金项目

广西壮族自治区卫生健康委员会2021年度西医类别自筹经费科研课题(20211111)

出版年

2024
临床医学研究与实践

临床医学研究与实践

ISSN：
段落导航相关论文