Effects of moxifloxacin and budesonide combined with non-invasive ventilation on ventilation capacity and prognosis in patients with community-acquired pneumonia and respiratory failure
Objective To investigate the effects of moxifloxacin and budesonide combined with non-invasive ventilation on ventilation capacity and prognosis in patients with community-acquired pneumonia(CAP)and respiratory failure(RF).Methods A total of 78 patients with CAP and RF admitted from January 2020 to December 2021 were selected as the research objects,and the patients were divided into control group and observation group according to coin tossing method,with 39 cases in each group.The control group was treated with conventional regimen and non-invasive ventilation,the observation group was treated with moxifloxacin and budesonide on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the blood oxygen saturation(SaO2)and partial pressure of oxygen(PaO2)in the observation group were higher than those in the control group,and the partial pressure of carbon dioxide(PaCO2)was lower than that in the control group(P<0.05).After treatment,the forced expiratory volume in one second(FEV1),forced vital capacity(FVC)and pulmonary dynamic compliance(Cdyn)in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of cysteinyl leukotrienes(CysLTs),soluble intracellular adhesion molecule-1(sICAM-1)and C-reactive protein(CRP)in the observation group were lower than those in the control group(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The moxifloxacin and budesonide combined with non-invasive ventilation in the treatment of CAP and RF can effectively improve the pulmonary ventilation capacity of patients,reduce the inflammatory reaction and promote the recovery of symptoms.
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