Comparison of clinical effects of concurrent chemoradiotherapy and sequential chemoradiotherapy in the treatment of patients with advanced esophageal cancer
Objective To compare the clinical effects of concurrent chemoradiotherapy and sequential chemoradiotherapy in the treatment of patients with advanced esophageal cancer.Methods The clinical data of 120 patients with advanced esophageal cancer admitted from January to December 2021 were retrospectively analyzed.According to the difference of chemoradiotherapy regimen,the patients were divided into concurrent group(74 cases)and sequential group(46 cases).The concurrent group was treated with concurrent chemoradiotherapy,and the sequential group was treated with sequential chemoradiotherapy.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the concurrent group was higher than that in the sequential group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the carcino-embryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 724(CA724),squamous cell carcinoma antigen(SCC),natural killer(NK)cells and tissue polypeptide antigen(TPA)levels between the two groups(P>0.05);after treatment,the levels of CEA,CA19-9,CA724,SCC and TPA in the concurrent group were lower than those in the sequential group,the NK cells was higher than that in the concurrent group,and the differences were statistically significant(P<0.05).The 1-year survival rate of the concurrent group was higher than that of the sequential group,the total incidence of adverse reactions was lower than that of the sequential group,and the differences were statistically significant(P<0.05).Conclusion Compared with sequential chemoradiotherapy,concurrent chemoradiotherapy has higher comprehensive efficacy and safety in the treatment of patients with advanced esophageal cancer,which is worthy of clinical promotion and application.
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