Effect of laparoscopic cholecystectomy combined with wedge resection of liver tissue and regional lymph node dissection in the treatment of early gallbladder cancer and its influences on tumor markers and inflammatory mediators levels
Objective To investigate the effect of laparoscopic cholecystectomy combined with wedge resection of liver tissue and regional lymph node dissection in the treatment of early gallbladder cancer.Methods A total of 86 patients with early gallbladder cancer admitted from March 2018 to March 2022 were selected as the research objects.According to the random number table method,the patients were divided into control group(43 cases,laparoscopic cholecystectomy)and observation group(43 cases,laparoscopic cholecystectomy combined with wedge resection of liver tissue and regional lymph node dissection).The therapeutic effects of the two groups were compared.Results The operation time of the observation group was longer than that of the control group,and the intraoperative blood loss was more than that of the control group(P<0.05);there were no significant differences in the recovery time of gastrointestinal function and hospitalization time between the two groups(P>0.05).After operation,the levels of carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)and carbohydrate antigen 242(CA242)in the observation group were lower than those in the control group(P<0.05).Before and after operation,there were no significant differences in the levels of interleukin-6(IL-6),C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)between the two groups(P>0.05).There was no significant difference in the total incidence of complications between the two groups(P>0.05);the 1-year recurrence rate of the observation group was lower than that of the control group(P<0.05).Conclusion Laparoscopic cholecystectomy combined with wedge resection of liver tissue and regional lymph node dissection in the treatment of early gallbladder cancer can prolong the operation time and increase the intraoperative blood loss,but it does not affect the postoperative recovery,and can further down-regulate the expression of tumor markers and improve the prognosis.
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