Effects of different doses of dexmedetomidine combined with ropivacaine transversus abdominis plane block on postoperative analgesic effect,stress response and cognitive function in laparoscopic radical resection of colorectal cancer
Objective To investigate the effects of different doses of dexmedetomidine combined with ropivacaine transversus abdominis plane block on postoperative analgesic effect,stress response and cognitive function in laparoscopic radical resection of colorectal cancer.Methods A total of 100 patients undergoing laparoscopic radical resection of colorectal cancer were selected and divided into control group and observation group by random number table method,with 50 cases in each group.The control group was given 0.5 μg/kg dexmedetomidine combined with ropivacaine for transversus abdominis plane block,and the observation group was given 1.0 μg/kg dexmedetomidine combined with ropivacaine for transversus abdominis plane block.The anesthetic effects of the two groups were compared.Results At 12,24 h after operation,the Visual Analogue Scale(VAS)score and the levels of bradykinin(BK),substance P(SP),cortisol(Cor)and norepinephrine(NE)of the observation group were lower than those of the control group(P<0.05).At 1,3 d after operation,the scores of Mini-Mental State Examination(MMSE)and Montreal Cognitive Assessment Scale(MoCA)in the observation group were higher than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion 1.0 μg/kg dexmedetomidine combined with ropivacaine for transversus abdominis plane block can improve postoperative analgesia effect,reduce stress response,and has little effect on cognitive function.
NETL
NSTL
万方数据
