Efficacy and safety of retinal photocoagulation combined with intravitreal injection of ranibizumab in the treatment of diabetic macular edema
Objective To analyze the efficacy and safety of retinal photocoagulation combined with intravitreal injection of ranibizumab in the treatment of patients with diabetic macular edema.Methods A total of 98 patients with diabetic macular edema admitted from January 2019 to June 2022 were selected as the research objects,and the patients were randomly divided into conventional group(49 cases,intravitreal injection of ranibizumab)and observation group(49 cases,retinal photocoagulation+intravitreal injection of ranibizumab).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the conventional group(P<0.05).From the second day after the third treatment(T3)to 30 d after the third treatment(T4),the uncorrected visual acuity(UCVA)and best corrected visual acuity(BCVA)in the observation group were higher than those in the conventional group(P<0.05);from the second day after the first treatment(T1)to T4,the macular fovealretinal thickness of the observation group was lower than that of the conventional group(P<0.05).After treatment,the fluorescence leakage area and resistance index(RI)in the observation group were lower than those in the conventional group,and the peak systolic velocity(PSV)and end diastolic velocity(EDV)were higher than those in the conventional group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Retinal photocoagulation combined with intravitreal injection of ranibizumab in the treatment of diabetic macular edema can effectively reduce the macular fovealretinal thickness of the affected eye,reduce the fluorescence leakage area,improve the hemodynamic indexes of the ophthalmic artery of the patients,and do not increase the adverse reactions,so as to achieve the safe and ideal effect.
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