Effect of Gualou Xiebai Guizhi decoction combined with conventional western medicine in the treatment of stable angina pectoris of coronary heart disease(phlegm turbidity internal obstruction syndrome)and its influence on oxidative stress response
Objective To explore the effect of Gualou Xiebai Guizhi decoction combined with conventional western medicine in the treatment of stable angina pectoris of coronary heart disease(phlegm turbidity internal obstruction syndrome).Methods A total of 92 patients with stable angina pectoris of coronary heart disease(phlegm turbidity internal obstruction syndrome)admitted from March 2020 to November 2022 were selected and divided into control group and observation group by random number table method,with 46 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Gualou Xiebai Guizhi decoction on the basis of the above.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)of the observation group was higher than that of the control group,and the left ventricular end-systolic diameter(LVESD)and left ventricular end-diastolic diameter(LVEDD)were smaller than those of the control group(P<0.05).After treatment,the level of malondialdehyde(MDA)in the observation group was lower than that in the control group,and the levels of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)were higher than those in the control group(P<0.05).After treatment,the level of nitric oxide(NO)in the observation group was higher than that in the control group,and the level of endothelin-1(ET-1)was lower than that in the control group(P<0.05).Conclusion The Gualou Xiebai Guizhi decoction combined with conventional western medicine in the treatment of stable angina pectoris of coronary heart disease(phlegm turbidity internal obstruction syndrome)has satisfactory effect,which can improve cardiac function and oxidative stress response,and repair vascular endothelial injury,it is worth promoting.
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