Atrophic gastritis,also known as chronic atrophic gastritis,is a chronic gastric disease caused by multiple of factors that induce atrophy of gastric mucosal epithelium and glandular cells,leading to thinning of mucosal epithelium.Atrophic gastritis is closely related to intestinal metaplasia and even canceration of gastric mucosa.Therefore,how to accurately diagnose it in clinical practice is the focus of monitoring atrophic gastritis.At present,the diagnosis of atrophic gastritis mainly depends on gastroscopy and gastric mucosal biopsy,but this examination procedure is complex and requires high skills from doctors,and the operation cost is high,so it is not suitable for the general screening of the population.Therefore,it is of great practical significance to find a convenient,fast and sensitive inspection method.In recent years,many studies have shown that pepsinogen(PG),gastrin-17(G-17)secreted by gastric mucosal epithelial cells and Helicobacter pylori(Hp)antibody in serum can effectively assist in the diagnosis of atrophic gastritis.This article reviews its research progress in atrophic gastritis,aiming to evaluate the clinical applicability of these three in screening and identifying atrophic gastritis.
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