Analysis of abnormal lipid metabolism and risk factors in patients with hypertensive disorder of pregnancy
Objective To investigate the abnormal lipid metabolism and risk factors in patients with hypertensive disorder of pregnancy(HDP).Methods A total of 209 HDP patients who received prenatal examination in our hospital from January 2020 to October 2022 were selected as observation group,and 100 pregnant women with normal blood pressure who received routine prenatal examination in our hospital during the same period were selected as control group.The levels of blood lipid indexes of the subjects were detected,and according to the blood lipid metabolism,the HDP patients were divided into normal group and abnormal group,the clinical data of the two groups were collected,and the binary Logistic regression analysis was used to explore the influencing factors of HDP patients complicated with abnormal blood lipid metabolism.Results The levels of low density lipoprotein cholesterol(LDL-C),triglyceride(TG)and total cholesterol(TC)in the observation group were higher than those in the control group,and the level of high density lipoprotein cholesterol(HDL-C)was lower than that in the control group,and the proportion of abnormal lipid metabolism was higher than that in the control group(P<0.05).Among HDP patients,136 cases had normal lipid metabolism and 73 cases had abnormal lipid metabolism;there were statistically significant differences in the proportion of weight gain,polycystic ovary syndrome,diabetes mellitus,the proportion of gestational hypertension/preeclampsia and eclampsia and mean arterial pressure(MAP)level between the normal group and the abnormal group(P<0.05).The levels of LDL-C and TG in the abnormal group were higher than those in the normal group,and the levels of HDL-C and apolipoprotein A1 were lower than those in the normal group(P<0.01).The results of binary Logistic regression analysis showed that high weight gain,polycystic ovary syndrome,diabetes mellitus,preeclampsia and eclampsia,LDL-C and TG were risk factors for HDP patients complicated with abnormal lipid metabolism,and HDL-C and apolipoprotein A1 were protective factors(P<0.05).Conclusion HDP patients have a higher risk of abnormal lipid metabolism.High weight gain during pregnancy,polycystic ovary syndrome,diabetes mellitus,preeclampsia and eclampsia,LDL-C,HDL-C,TG and apolipoprotein A1 all affect the occurrence of abnormal lipid metabolism,which needs clinical attention.
hypertensive disorder of pregnancyabnormal lipid metabolismeclampsia
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