Expression characteristics of IL-6,IL-10 and SIRI in peripheral blood of patients with bacterial pneumonia infection
Objective To investigate the expression characteristics of peripheral blood inflammatory markers in patients with bacterial pneumonia infection,and to analyze its relationship with the severity of the disease.Methods Fifty patients with severe pneumonia(SP)who were admitted in the Third People's Hospital in Liaocheng from January 2023 to January 2024 were selected as SP group,and 43 patients with non-severe pneumonia(NSP)who were hospitalized during the same period were selected as NSP group and 30 healthy physical examination stations were selected as healthy control(HC)group.The levels of tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),interleukin-2(IL-2),interleukin-4(IL-4),interleukin-6(IL-6),interleukin-10(IL-10),high sensitivity C-reactive protein(hs-CRP)and procalcitonin(PCT)and neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),monocyte-to-lymphocyte ratio(MLR),systemic immune-inflammation index(SII)and systemic inflammation response index(SIRI)were compared among the three groups.Multivariate Logistic regression analysis was used to analyze the influencing factors of SP,and the receiver operating characteristic(ROC)curve was used to evaluate the diagnostic efficacy of related indicators for SP.Results The levels of IL-6,IL-10,hs-CRP and NLR,PLR,MLR,SII,SIRI in the NSP group and the SP group were significantly higher than those in the HC group,and the differences were statistically significant(P<0.05);the levels of IL-6,IL-10,hs-CRP,PCT,NLR,SII and SIRI in the SP group were significantly higher than those in the NSP group,and the differences were statistically significant(P<0.05);the PCT level of the SP group was significantly higher than that of the HC group,and the difference was statistically significant(P<0.05).Multivariate Logistic regression analysis showed that IL-6,IL-10 and SIRI were independent risk factors for SP(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of IL-6,IL-10 and SIRI alone diagnosed SP were 0.918,0.793 and 0.719,respectively;the AUC of IL-6+IL-10+SIRI in the diagnosis of SP was 0.952,the sensitivity was 87.76%,and the specificity was 92.86%.Conclusion The detection of peripheral blood inflammatory markers is helpful to evaluate the severity of bacterial pneumonia.IL-6,IL-10 and SIRI are independent risk factors for SP,and the combination of the three is more valuable for the diagnosis of SP.
bacterial pneumoniainterleukin-6interleukin-10systemic inflammation response index
NETL
NSTL
万方数据
