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重复经颅磁刺激对男性精神分裂症患者代谢指标的影响

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目的 探讨重复经颅磁刺激(rTMS)对男性精神分裂症患者体重指数(BMI)、腰围、血压、空腹血糖(FBG)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)的影响。方法 将52 例男性精神分裂症患者按随机数字表法分为观察组(27例)和对照组(25例)。观察组在奥氮平片治疗的基础上联合rTMS治疗,对照组在奥氮平片治疗的基础上联合经颅磁伪刺激治疗。比较两组的治疗效果;分析联合rTMS治疗对男性精神分裂症患者代谢指标的影响。结果 观察组的治疗总有效率为 92。59%,高于对照组的72。00%,差异具有统计学意义(P<0。05)。治疗4周后,观察组的TG、HDL-C异常占比低于对照组,差异具有统计学意义(P<0。05)。治疗后,两组的BMI、TG水平高于治疗前,腰围大于治疗前,HDL-C水平低于治疗前,差异具有统计学意义(P<0。05);治疗后,观察组的TG水平低于对照组,HDL-C水平高于对照组(P<0。05)。结论 联合rTMS治疗可减轻男性精神分裂症患者代谢指标异常情况。
Effects of repetitive transcranial magnetic stimulation on metabolic indexes in male patients with schizophrenia
Objective To investigate the effects of repetitive transcranial magnetic stimulation(rTMS)on body mass index(BMI),waist circumference,blood pressure,fasting blood glucose(FBG),triglycerides(TG)and high density lipoprotein cholesterol(HDL-C)in male patients with schizophrenia.Methods Fifty-two male patients with schizophrenia were divided into observation group(27 cases)and control group(25 cases)by random number table method.The observation group was treated with rTMS on the basis of olanzapine tablets,and the control group was treated with transcranial magnetic pseudo stimulation on the basis of olanzapine tablets.The therapeutic effects of the two groups were compared;the effect of combined rTMS treatment on metabolic indexes in male patients with schizophrenia was analyzed.Results The total effective rate of treatment in the observation group was 92.59%,which was higher than 72.00%in the control group,and the difference was statistically significant(P<0.05).After 4 weeks of treatment,the proportion of abnormal TG and HDL-C in the observation group were lower than those in the control group,and the difference were statistically significant(P<0.05).After treatment,the levels of BMI and TG in the two groups were higher than those before treatment,and the waist circumference was greater than that before treatment,and the HDL-C level was lower than that before treatment,and the difference were statistically significant(P<0.05);after treatment,the TG level of the observation group was lower than that of the control group,and the HDL-C level was higher than that of the control group(P<0.05).Conclusion Combined with rTMS treatment can reduce the abnormal metabolic indexes in male patients with schizophrenic.

repetitive transcranial magnetic stimulationschizophreniametabolic index

祝希泉、段惠峰、梁学军

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联勤保障部队第九八八医院全军精神疾病防治研究所,河南 焦作,454003

重复经颅磁刺激 精神分裂症 代谢指标

河南省医学科技攻关计划项目

LHGJ20220906

2024

临床医学研究与实践

临床医学研究与实践

ISSN:
年,卷(期):2024.9(25)