Effect of ticagrelor combined with felodipine on angina pectoris of coronary heart disease and its influences on expression of COMP and LTBP-2
Objective To investigate the effect of ticagrelor combined with felodipine on angina pectoris of coronary heart disease and its influences on expression of cartilage oligomeric matrix protein(COMP)and latent transforming growth factor binding protein 2(LTBP-2).Methods A total of 84 patients with angina pectoris of coronary heart disease admitted from January 2021 to July 2022 were selected as the research objects and divided into control group and observation group by random number table method,with 42 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with felodipine,and the observation group was treated with ticagrelor combined with felodipine.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the frequency of angina pectoris in the observation group was lower than that in the control group,and the duration of angina pectoris was shorter than that in the control group(P<0.05).After treatment,stroke volume(SV),cardiac output(CO)and ratio of peak early diastolic flow velocity to peak atrial diastolic flow velocity(E/A)in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of COMP and LTBP-2 in the observation group were lower than those in the control group(P<0.05).Conclusion The ticagrelor combined with felodipine in the treatment of angina pectoris of coronary heart disease has a significant effect,it can effectively reduce the frequency of angina pectoris,shorten the duration of attack,improve cardiac function,and reduce the levels of COMP and LTBP-2,which is worth promoting.
ticagrelorfelodipineangina pectoris of coronary heart diseasecardiac function
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