Application effect of liraglutide in elderly patients with type 2 diabetes mellitus and coronary heart disease and its influences on TNF-α and CRP levels
Objective To analyze the application effect of liraglutide in elderly patients with type 2 diabetes mellitus(T2DM)and coronary heart disease(CHD).Methods A total of 90 elderly patients with T2DM and CHD admitted from January 2020 to December 2022 were selected as the research objects.According to the difference of treatment plan,and the patients were divided into control group(n=45,routine comprehensive therapy)and study group(n=45,combined with liraglutide treatment on the basis of the control group).The blood glucose,blood lipid and cardiac function indexes,inflammatory and vascular endothelial factors and clinical efficacy were compared between the two groups.Results After treatment,the fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)levels in the study group were lower than those in the control group,and left ventricular ejection fraction(LVEF)and early/late diastolic mitral flow velocity ratio(E/A)were higher than those in the control group(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and chitinase protein 40(YKL-40)in the study group were lower than those in the control group,and the levels of peroxisome proliferators activated receptor γ(PPARγ),visceral adipose tissue-derived serine protease inhibitor(Vaspin)and Ghrelin were higher than those in the control group(P<0.05).The total effective rate of treatment in the study group was significantly higher than that in the control group(P<0.05).Conclusion Liraglutide is beneficial to regulate the levels of blood glucose,blood lipids and inflammatory and vascular endothelial factors in elderly patients with T2DM and CHD,and improve cardiac function,it is worthy of clinical promotion and application.
type 2 diabetes mellituscoronary heart diseaseliraglutide
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NSTL
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