Effect of combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus cereus tablets,live combined with rabeprazole quadruple therapy on Hp infectious peptic ulcer in the elderly
Objective To explore the effect of combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus cereus tablets,live combined with rabeprazole quadruple therapy in the treatment of Helicobacter pylori(Hp)infectious peptic ulcer in the elderly.Methods A total of 240 elderly patients with Hp infectious peptic ulcer admitted in our hospital were divided into control group and observation group by random number table method,with 120 cases in each group.The control group received rabeprazole quadruple therapy,and the observation group received combined Bifidobacterium,Lactobacillus,Enterococcus and Bac illus cereus tablets,live on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the numbers of Bifidobacterium and Lactobacillus in the observation group were more than those in the control group(P<0.05).After treatment,the level of gastrin(GAS)in the observation group was higher than that in the control group,and the expression levels of thioredoxin-1(Trx1)and C-myc protein were lower than those in the control group(P<0.05).After treatment,the levels of transforming growth factor-β1(TGF-β1),interleukin-17(IL-17)and interleukin-8(IL-8)in the observation group were lower than those in the control group(P<0.05).Conclusion Combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus cereus tablets,live combined with rabeprazole quadruple therapy in the treatment of elderly Hp infectious peptic ulcer can improve the body's inflammatory state and gastrointestinal flora,inhibit the expression of Trx1 and C-myc proteins,and enhance the overall therapeutic effect.
combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus cereus tablets,liveHelicobacter pyloripeptic ulcergastrointestinal flora
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